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Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 59-62

Peculiarities of renal cell carcinoma in young adults

Department of Surgery, Ahmadu Bello University, Teaching Hospital, Zaria, Nigeria

Correspondence Address:
Dr. Nasir Oyelowo
Department of Surgery, Ahmadu Bello University, Zaria, Kaduna
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ais.ais_33_18

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Background: We observed an increase in incidence of sporadic renal cell carcinoma in young adults (< 40years). The presentation and outcome seems to be different from those in the elderly. We retrospectively reviewed the clinical presentations, pathological findings, management and outcomes in these patients as well as comparison with those in older patients. Patients and Methods: The age, clinical presentation, pathological findings and outcomes following treatment of patients diagnosed and managed for renal cell carcinoma at this center from January 2008 to January 2017 were retrieved from hospital records and analyzed. Patients where divided into young adults (< 40 years) or older adults (> 40 years). Results: A total of 61 patients were reviewed within the period with young adults n = 25 (41%) vs older adults n = 36 (59%). A male:female ratio of 2:1 was found in both groups. Flank pain (77.8% in older adults compared to 72% in young adults) and Hematuria (63.9% of Older adults compared to 52.0% of Young adults.) were both higher in older adults but not statistically significant with P values not <0.05 however Flank mass (100% in older adults and 72.0% in younger adults) was also higher in older adults as well as statistically significant with P value of 0.001. Metastasis and stage of the diseases were equally statistically significantly higher in older adults with P values 0.001. Mean 5 year survival in months for young adults was 25 months (56-3 months) and older adults was 15 months (45- 5 months). Conclusion: Sporadic RCC in young adults presents commonly with an early disease. It seldoms presents with flank mass as compared to the older adults. Hematuria, flank pain and histological type and grade occurs in similar distribution in both groups survival was better in the young.

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