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Year : 2016  |  Volume : 6  |  Issue : 4  |  Page : 240

Granulomatous lobular mastitis

Consultant Endoscopic and Laparoscopic Surgeon, Ronak Endo-laparoscopy and General Surgical Hospital, Patan, Gujarat, India

Date of Web Publication8-Dec-2017

Correspondence Address:
Vipul Yagnik
Consultant Endoscopic and Laparoscopic Surgeon, Ronak Endo-laparoscopy and General Surgical Hospital, Patan, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ais.ais_2_17

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How to cite this article:
Yagnik V. Granulomatous lobular mastitis. Arch Int Surg 2016;6:240

How to cite this URL:
Yagnik V. Granulomatous lobular mastitis. Arch Int Surg [serial online] 2016 [cited 2023 Sep 28];6:240. Available from:


I read an article entitled “Chronic granulomatous mastitis: A therapeutic dilemma revisited”[1] with interest. I would like to congratulate the authors for their effort in writing the topic concisely. However, I would like to add few more information regarding this entity, which you may find useful.

Granulomatous mastitis involving breast tissue is uncommon. Non-necrotising granulomatous inflammation, that is idiopathic, is referred to as granulomatous lobular mastitis.[2] The etiology of granulomatous lobular mastitis is unknown, although infection with Corynebacterium is implicated in some series.[2] In addition to staining for acid fast bacilli and culturing for aerobic and anaerobic bacteria, special stain for fungal organisms helps to rule out Nocardia as a cause of granulomatous mastitis.[3] Ogura et al.[4] offer new insight in to the nature of granulomatous lobular mastitis. They found that granulomatous lobular mastitis showed specific clinicopathologic features such as lobulocentric inflammation with giant cells, diffuse immunoglobulin G4+, and high level of serum IgG4. They concluded that granulomatous lobular mastitis can be either IgG4 related or not related. Further, it could help to avoid over treatment.[4]

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  References Top

Kshirsagar VV, Male PV, Bendre M, Chavan S, Rathod S. Chronic granulomatous mastitis: A therapeutic dilemma revisited. Arch Int Surg 2016;6:100-4.  Back to cited text no. 1
  [Full text]  
Timothy M, Alfonso D. Inflammatory, reactive and infective condition of the breast. In: Shin SJ, editor. Comprehensive guide to core needle biopsies of the breast. Switzerland: Springer; 2016. pp. 135-60.  Back to cited text no. 2
Sabel MS. Infectious and inflammatory disease of the breast. In: Sabel MS, editor. Essential of breast surgery. Philadelphia: Mosby Elsevier; 2009. pp. 83-90.  Back to cited text no. 3
Ogura K, Matsumoto T, Aoki Y, Kitabatake T, Fujisawa M, Kojima K. IgG4 related tumor forming mastitis with histological appearance of granulomatous lobular mastitis: Comparison with other form of mastitis. Histopathology 2010;57:39-45.  Back to cited text no. 4


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