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Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 101-104

Familial adenomatous polyposis coli and adenocarcinoma of the colon: A silent synchronous presentation

Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India

Correspondence Address:
M Srinivasamurthy
Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-9596.110029

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Familial adenomatous polyposis (FAP) coli is an autosomal dominant syndrome characterized by germline mutation of adenomatous polyposis coli (APC) gene resulting in intestinal adenomatous polyposis and a very high incidence of transformation to colorectal adenocarcinoma. A 57-year-old male presented with watery diarrhea, pain abdomen and weight loss since 2 years. A clinical diagnosis of malabsorption syndrome was made. Upper gastrointestinal endoscopy did not reveal any lesions. Colonoscopy showed numerous polyps throughout the colon without any evidence of malignancy. Total proctocolectomy with ileostomy was done. Excised specimen showed APC with two foci of invasive adenocarcinoma in the transverse and descending colon. Studies indicate that FAP coli can transform to adenocarcinoma and hence we go by the fact that same is the scenario in our case. We present this interesting case with clinical and pathological findings.

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